Guide//5 min
Bloodwork on a GLP-1
Most people on these drugs are monitored on a bathroom scale and nothing else. A short, cheap panel twice a year would catch nearly everything that quietly goes wrong.
Your Body
Nutrition
Eating well on a fraction of your former appetite.
48 pieces
Guide//5 min
Coffee on a GLP-1
Nobody is going to tell you to give up coffee, and nobody should. But it interacts with three things this drug class has already made more fragile, and the interactions are all avoidable.
Guide//5 min
Constipation on a GLP-1
Nausea gets the attention because it arrives first and loudly. Constipation arrives in week three, never fully resolves for some people, and is the thing they eventually stop over.
Guide//6 min
Dehydration and your kidneys
Acute kidney injury on this drug class is almost never a direct drug effect. It is three days of vomiting in someone who did not think to replace the fluid, and it is entirely avoidable.
Guide//5 min
Teeth and dental work
Repeated vomiting erodes enamel permanently, reflux does it more quietly, and any dental procedure involving sedation now needs the same conversation as surgery. None of this is on the leaflet.
Guide//5 min
Diarrhoea on a GLP-1
A drug famous for slowing the gut down produces loose stools in a substantial minority, which sounds contradictory until you know what else is usually in the picture.
Guide//5 min
Donating blood on a GLP-1
No blood service in the United States defers you for taking one of these. What will defer you is the iron, the weight and the hydration — three things this drug class makes considerably more likely.
Guide//6 min
Exercising on a GLP-1
The advice to exercise while losing weight is correct and almost always delivered by someone who has not tried doing it on nine hundred calories and a stomach that empties at half speed.
Explainer//5 min
Gallstones on a GLP-1
Rapid weight loss has caused gallstones for as long as people have lost weight rapidly. What these drugs added was the speed, the scale, and a great many people discovering it at once.
Explainer//6 min
A1c on a GLP-1
Roughly one and a half to two points for semaglutide, and more than two for tirzepatide. The more interesting question is why the number lags a month behind everything you are doing.
Explainer//5 min
GLP-1s through menopause
The weight that appears in the forties and fifties is not a failure of discipline. It is a redistribution driven by falling oestrogen, and it responds to a different set of interventions than the ones that worked at thirty.
Explainer//5 min
GLP-1s and PCOS
These drugs address the insulin resistance sitting underneath polycystic ovary syndrome, which is why they work. Restoring ovulation in women who believed they could not conceive is the part nobody prepares for.
Explainer//6 min
GLP-1s for teenagers
Wegovy has been licensed for twelve-year-olds since 2022 and the trial data is strong. The disagreement is not really about whether the drug works, which is why it has not resolved.
Guide//5 min
How to start a GLP-1
Most of what determines how your first year goes is decided in the fortnight before the first injection, by questions nobody thinks to ask until much later.
Guide//6 min
Loose skin after a GLP-1
Skin keeps tightening for a year or more after the weight stops coming off, which means most people who panic at month eight are looking at an unfinished result.
Explainer//6 min
The "natural Ozempic" question
Berberine, apple cider vinegar, fibre blends and anything sold as a GLP-1 activator. Some of them do something measurable. None of them does the thing they are being bought for.
Guide//6 min
Reflux on a GLP-1
A stomach that empties slowly is a stomach that stays full longer, and a full stomach lying flat has only one direction to go. Most of the fix is mechanical rather than pharmacological.
Guide//5 min
Sulfur burps on a GLP-1
The rotten-egg burp is one of the most reliably reported side effects on tirzepatide and one of the least discussed in clinic, largely because nobody wants to be the person raising it.
Guide//6 min
Why weight loss stalls
Every weight loss curve flattens. The trial curves flatten, the surgical curves flatten, and yours will too. The question is whether you have hit a plateau or simply had a fortnight.
Guide//7 min
What to eat on a GLP-1
Appetite suppression solves the quantity problem and creates a composition one. Every bite now has to do more work, and most people spend month one finding this out the hard way.
Guide//3 min
Best supplement for GLP-1 constipation
The drug slows your stomach on purpose. Constipation is not a malfunction, it is the mechanism doing its job further down the tract than anyone wanted — which is why the fix is mechanical rather than clever.
Guide//4 min
Best creatine for GLP-1 users
Creatine monohydrate is a commodity costing pennies a gram, and it is the single best-evidenced supplement for holding on to strength while you lose a fifth of your body weight. The interesting question is what else is in the scoop.
Guide//2 min
Best electrolytes for GLP-1 users
Thirst tracks eating. Halve the food and you quietly halve the fluid and the sodium that came with it, which is why so much of what gets blamed on the drug is ordinary dehydration wearing a costume.
Guide//3 min
Best GLP-1 supplement brand
Every brand in this category claims transparency. Only some of them print the numbers that would let you check, and the gap between those two groups is the most useful thing a buyer can know.
Guide//4 min
Best GLP-1 supplement stack
Most of the supplements sold to people on Ozempic are designed to raise GLP-1. You are already injecting a GLP-1 agonist. The useful question is what the drug leaves behind, and which stack is built to replace it.
Guide//2 min
Best GLP-1 supplements over 50
Age-related muscle loss was already running before you started. A GLP-1 adds a second subtraction on top of the first, and the arithmetic of that is the whole reason this ranking looks different.
Guide//2 min
Best GLP-1 supplements for women
Most supplement advice for this drug is written for a generic body. Menstrual iron losses, bone density during rapid loss, and a documented contraceptive interaction make the picture genuinely different.
Guide//4 min
Best metabolic supplement on a GLP-1
Berberine got called nature's Ozempic by people who had not looked closely at either. It is a real compound with real effects and a real interaction profile, and it is the one shelf in this market where I would want your prescriber involved before your wallet.
Guide//3 min
Best muscle supplement on a GLP-1
A quarter to a third of what you lose on these drugs is lean tissue. No powder changes that on its own — but two of them meaningfully help, and the rest are selling you the idea of help.
Guide//3 min
Best probiotic for GLP-1 users
Slowed gastric emptying is the mechanism that makes these drugs work and the mechanism that stops your bowels. Whether a probiotic helps depends entirely on which of those two problems you actually have.
Guide//3 min
Best skin support on a GLP-1
The hollowing people notice at month six is lost facial fat, not tired skin. Nothing in a bottle puts that back — which makes the honest question what a serum or a supplement can still usefully do.
Guide//2 min
Best supplements: first 30 days
Week one is not the time to build a stack. It is the time to find out how your body handles the drug, with the smallest number of variables you can manage.
Guide//2 min
Best supplements for GLP-1 fatigue
Tiredness on these drugs has four common causes and only one of them is fixed by a supplement you can buy today. Working out which one you have is worth more than anything in this ranking.
Guide//2 min
Best supplements coming off a GLP-1
Appetite returns faster than muscle does. The months after you stop are when the lean mass you did not defend becomes a number you can feel, and the supplement priorities invert accordingly.
Guide//2 min
Best supplements for GLP-1 nausea
Nausea is the mechanism, not a malfunction, which sets a hard ceiling on what any supplement can do. Within that ceiling there is one cheap option with real trial evidence and a great deal of expensive noise.
Guide//2 min
Best supplements on semaglutide
Semaglutide's signature is gastrointestinal. Nausea, reflux and constipation shape what you can physically swallow, which makes tolerability the first ranking criterion rather than an afterthought.
Guide//2 min
Best supplements on tirzepatide
Tirzepatide takes off more weight than any injectable before it, and the supplement question changes with the magnitude. When a fifth of your body is leaving, what you protect matters more than what you optimise.
Guide//2 min
Best supplements for training on a GLP-1
Resistance training is the highest-leverage thing you can do on these drugs and the hardest to sustain, because you are being asked to train in a deficit with an appetite that will not cooperate.
Guide//3 min
Best value GLP-1 supplements
Creatine, psyllium and a multivitamin are commodities. Put a GLP-1 label on the tub and the price roughly triples, which is a marketing achievement rather than a pharmacological one.
Guide//3 min
Do you need GLP-1 supplements?
An entire industry has assembled around the answer being yes. The defensible answer is that two products help most people, two help some, and the rest exist because you are a motivated buyer with a new prescription.
Guide//10 min
The GLP-1 companion app I recommend
Almost every avoidable failure I see in the first year of treatment traces back to the same thing: nobody wrote anything down. Here is what is worth recording, why it matters more on these drugs than on anything else I prescribe, and the tool I have settled on.
Guide//6 min
The first eight weeks on a GLP-1
Nobody is short of opinions about these drugs. What people are short of is a clear account of the first two months — what the body does, when, and which parts of it are worth a phone call.
Explainer//4 min
What a GLP-1 receptor agonist actually does
The mechanism is usually explained either in cartoon form or in a wall of pharmacology. Here is the version in between — enough to reason with, without pretending the picture is complete.
Explainer//5 min
The hair loss question
Hair shedding after starting a GLP-1 is real, common enough to be worth naming, and in most cases caused by the speed of the weight loss rather than the drug producing it.
Deep Dive//5 min
Food noise
Nobody measured it, no trial listed it as an endpoint, and it is the single most common thing patients volunteer unprompted. The most consequential effect of these drugs may be one we have no instrument for.
Guide//5 min
How much protein on a GLP-1
The number is not the hard part. Getting a hundred and twenty grams into a body that stops being interested after four bites is a logistics problem, and it deserves to be treated as one.
Deep Dive//5 min
The muscle question
Roughly a quarter of the weight lost on a GLP-1 is not fat. Whether that matters, and what — if anything — you can do about it, is the most consequential unsettled argument in this field.
Guide//5 min
Lifting on a GLP-1: the minimum that works
You do not need a program, a coach, or a gym membership you will cancel in March. You need six movements, twice a week, and enough load that the last two repetitions are genuinely difficult.
Also in Your Body
On The Jab
The
GLP‑1
Handbook
Dr. Nick Robertson
MD
The book · 14 chapters
The GLP-1 Handbook
Everything I tell my own patients before their first injection. 214 pages of what actually matters in the first year — dosing, side effects, food, muscle, cost, and the part nobody prepares you for: maintenance.
$4Less than your morning coffee.
Priced at four dollars because it should be affordable to everyone taking these drugs — not because it's worth four dollars. No upsell, no course, no supplement line.