Explainer//5 min
Every GLP-1 medication
There are more of these than the two everyone talks about, several are considerably older, and a few are still widely prescribed for reasons that have nothing to do with weight.
Medications
Next Generation
Orforglipron, retatrutide, CagriSema and the oral wave.
6 pieces
Deep Dive//5 min
The oral GLP-1 is coming
An effective GLP-1 in tablet form is not mainly a convenience story. It is a manufacturing story — and manufacturing is what has rationed these drugs since the day they arrived.
Explainer//4 min
The race past 20 percent
Retatrutide, CagriSema and the triple agonists are aiming at weight reduction that used to require surgery. The interesting question is no longer whether they can get there, but what breaks first.
News//3 min
The semaglutide pill arrives
An oral GLP-1 for obesity removes the needle, the fridge and a good deal of the friction. It also comes with rules about how you take it that people underestimate badly.
News//4 min
Drugs to protect muscle alongside GLP-1s
If a quarter of the weight you lose is lean tissue, the obvious pharmaceutical response is a second drug to stop that happening. Several are now in trials, and the questions they raise are more interesting than the marketing.
Explainer//5 min
GLP-1s and alcohol
A striking number of people on these drugs report simply losing interest in alcohol. It was nobody's design goal, the mechanism is unresolved, and it may turn out to be one of the most consequential things this class does.
On The Jab
The
GLP‑1
Handbook
Dr. Nick Robertson
MD
The book · 14 chapters
The GLP-1 Handbook
Everything I tell my own patients before their first injection. 214 pages of what actually matters in the first year — dosing, side effects, food, muscle, cost, and the part nobody prepares you for: maintenance.
$4Less than your morning coffee.
Priced at four dollars because it should be affordable to everyone taking these drugs — not because it's worth four dollars. No upsell, no course, no supplement line.